Dr. Sreyleak Luch, a physician in Cambodia, suspected a case of bird flu in a 9-year-old boy, Virun, who later died of highly pathogenic avian influenza. This incident highlighted the importance of Cambodia's disease tracking system and its role in global biosurveillance. The country's efforts in disease detection and containment have been supported by international and local investments, training, and public education. The article also discusses the global threat of H5N1, a virus causing influenza in birds, and the recent cases of human infection in Cambodia. The country's disease surveillance system, led by Dr. Ly Sovann, has been instrumental in detecting and responding to such outbreaks. However, challenges remain, including the need for improved surveillance of animals and public education on avian influenza. The article emphasizes the critical role of frontline healthcare workers in preventing and managing potential pandemics.