Oprah Winfrey's return to television with a special on weight loss drugs like Ozempic and Wegovy is a personal narrative of her own struggles with weight. The program explores the rebranding of the weight-loss industry, framing obesity as a disease rather than a personal failing. It delves into the inequality of obesity treatments and the ongoing cultural and physiological complexities of weight loss. The special also highlights the impact of new weight-loss drugs on the fitness and weight-loss industries, as well as the challenges of insurance coverage and affordability. Ultimately, it reflects on Oprah's own journey and her quest to find love for her body.